Cognitive symptoms like brain fog and irritability are caused by hormonal changes during perimenopause and menopause, not by a loss of mental stability [1, 2].
These insights help women distinguish between temporary hormonal shifts and permanent cognitive decline. Understanding the physiological root of these symptoms can reduce anxiety and encourage women to seek medical support for manageable conditions.
Dr. Stephanie Liu, known as "Dr. Mom," discussed the issue on CTV News on June 4 [1]. She said that hormonal changes during perimenopause can cause real cognitive changes, not a mental health crisis [1]. These changes occur because fluctuating estrogen and other hormone levels affect brain chemistry during the transition to menopause [1, 2].
Some women experience these symptoms earlier than expected. Grace Presley began experiencing symptoms when she was 39 years old [3]. "I thought I was losing my mind," Presley said [3].
The prevalence of these symptoms is significant. Approximately 64.3% of women aged 36-40 report moderate or severe perimenopausal symptoms [4]. Despite the frequency of these occurrences, many women do not seek professional help.
Rachel Pope said that most women do not talk to their doctors about these symptoms, even though they are common [2]. This lack of communication contributes to a gap in diagnosis and recognition. While some reports suggest women simply do not consult their physicians, other findings indicate that healthcare providers often fail to recognize or diagnose perimenopause when women do seek help [2, 4].
Addressing these cognitive shifts requires a shift in how the medical community and patients view the menopausal transition. By identifying the role of estrogen in brain function, providers can offer targeted support to the majority of women facing these challenges [1, 2].
“"Hormonal changes during perimenopause can cause real cognitive changes, not a mental health crisis,"”
The disconnect between the high prevalence of perimenopausal symptoms and the rate of medical diagnosis suggests a systemic gap in women's healthcare. By framing brain fog and irritability as endocrine-driven cognitive changes rather than psychological failures, the medical community can move toward standardized screening for women in their late 30s and early 40s.





