The U.S. Centers for Disease Control and Prevention is coordinating with healthcare, animal health, and agricultural partners to combat drug-resistant infections [1].

This collaboration is critical because antimicrobial resistance threatens human lives and the stability of the agricultural and healthcare industries [1, 4]. Without effective interventions, the drugs used to treat common infections could become obsolete, leaving patients vulnerable to previously treatable diseases [4].

The CDC's strategy focuses on the prevention, detection, and response to infections that have evolved to resist standard medical treatments [1, 2]. By monitoring these patterns, the agency aims to preserve the utility of both antibiotics and antifungal medications [1, 2]. This systemic approach recognizes that resistance does not only exist in hospitals, but also within the broader environment and animal populations [1].

Efforts to address this challenge are ongoing and were highlighted as a priority throughout 2025 [3]. The agency works across sectors to ensure that antimicrobial drugs are used judiciously, a practice intended to slow the rate at which bacteria and fungi develop resistance [1].

Because antimicrobial resistance affects multiple sectors, the CDC integrates data from animal health and agriculture to create a comprehensive surveillance network [1]. This interdisciplinary coordination allows public health officials to identify emerging threats more quickly and deploy targeted responses to prevent widespread outbreaks [1, 2].

The CDC's strategy focuses on the prevention, detection, and response to infections that have evolved to resist standard medical treatments.

The CDC's shift toward a cross-sector approach reflects the 'One Health' model, acknowledging that human health is inextricably linked to the health of animals and the shared environment. By integrating agricultural and veterinary data with clinical healthcare, the U.S. is attempting to close the gap in surveillance that often allows resistant strains to migrate undetected between livestock and humans.