Erin Moriarty said the season five finale of "The Boys" was heartbreaking and discussed how health challenges affected her role as Annie [1, 2].

This admission provides insight into the personal struggles of the cast during the production of the series' conclusion, highlighting the intersection of chronic illness and professional performance.

Moriarty publicly disclosed her diagnosis of Graves’ disease in June 2025 [1]. The autoimmune condition impacted her ability to engage with her character's arc during the final stretch of the show. She said, "It did lead to me not being as present for Annie during this final season as I would’ve hoped, and that was super painful for me" [2].

Despite these difficulties, the actress noted a shift in her experience as the production reached its climax. She said, "I finally felt present at the very end of season five" [1]. This emotional return coincided with the narrative resolution for Annie and Hughie.

Regarding the character's journey, Moriarty said that Annie’s plan was a testament to how she perseveres [3]. The finale's emotional weight was a focal point for the actress, who reflected on the narrative outcome for the couple in interviews published earlier this month [1, 3].

As the series concludes, the production's rollout included providing critics with seven out of eight episodes of season five for review [4]. This approach allowed for a concentrated analysis of the season's trajectory leading into the finale.

"It did lead to me not being as present for Annie during this final season as I would’ve hoped, and that was super painful for me."

Moriarty's transparency regarding Graves' disease underscores the physical and mental toll of managing a chronic illness while maintaining a high-profile acting role. By linking her health struggles to her perceived absence in the final season, she provides a context for the character's portrayal that differs from the scripted narrative, reflecting the reality of working through health crises in the entertainment industry.