Women with primary infertility may experience the onset of natural menopause about one year earlier than those without the condition [1].
This finding suggests a critical link between reproductive challenges and the long-term trajectory of ovarian health. Understanding this connection allows clinicians to better predict the timing of menopause and manage the associated health transitions for at-risk women.
The research, published by the Menopause Society, indicates that primary infertility is associated with a higher risk of early menopause before age 45 [2]. This risk is particularly pronounced in women who have endometriosis or those categorized with unexplained infertility [2].
Researchers said the underlying cause of this trend may be related to ovarian reserve. Infertility may reflect a reduced number of follicles in the ovaries, which leads to an earlier depletion of those follicles over time [3]. This depletion is the biological driver that triggers the transition into menopause.
Among the different types of infertility, the study found that the strongest association between infertility and early menopause occurs in women with endometriosis [2]. While the average difference in timing is approximately one year [1], the increased likelihood of reaching menopause before 45 remains a significant clinical marker for those with primary infertility [2].
The Menopause Society said these findings highlight the importance of longitudinal tracking for women facing fertility struggles. By identifying these risks early, healthcare providers can offer more tailored support, and monitoring as patients approach their reproductive transition [4].
“Women with primary infertility experience natural menopause about one year earlier on average.”
This study indicates that primary infertility is not merely a challenge to conception but may be a biomarker for overall ovarian longevity. By linking reduced ovarian reserve to both infertility and earlier menopause, the research suggests that the biological clock for some women may be accelerated, necessitating earlier interventions and specialized health screenings for cardiovascular and bone health that often decline after menopause.
