Infertility and Endometriosis Linked to Early Menopause Risk

Women with a history of endometriosis or unexplained primary infertility face a higher risk of entering natural menopause before age 45 ^[1].

This association suggests that reproductive health challenges earlier in life may serve as markers or drivers for a shorter reproductive window. Identifying these risk factors allows healthcare providers to offer more targeted monitoring and support for women who may face an earlier transition into postmenopause.

Findings published by the Menopause Society this month indicate that early menopause is specifically defined as occurring before age 45 ^[1]. The research highlights a significant connection between these conditions and the timing of the final menstrual period.

According to the study, women with a history of primary infertility experienced natural menopause about one year earlier on average than those without such histories ^[2].

Researchers utilized Cox proportional hazards and linear regression to determine the statistical association ^[3]. To ensure the accuracy of the link, the analysis adjusted for several variables, including body mass index, race, and tobacco use ^[3]. The study also accounted for contraception history, and the regularity of the participants' menstrual cycles ^[3].

While the study identifies a correlation, it focuses on natural menopause rather than surgically induced menopause. The data suggests that the underlying biological factors contributing to infertility or endometriosis may also influence the depletion of ovarian reserves over time ^[3].