Iran's Islamic Revolutionary Guard Corps launched a multi-layered missile barrage against U.S. and Israeli targets overnight on Tuesday [1, 2].

This escalation marks a significant intensification of the ongoing Iran-Israel conflict, directly targeting U.S. military personnel and strategic regional assets to pressure the American presence in the Middle East [1, 5].

The IRGC launched the 35th, 36th, and 37th waves of an operation titled "True Promise 4" [1]. The barrage lasted approximately three hours [1], though other reports indicate the broader campaign of attacks has continued for 10 straight nights [3].

Targets included Tel Aviv, Israel, and U.S. positions in Erbil, Iraq [1, 4]. The strikes also hit facilities linked to the U.S. Navy’s Fifth Fleet in Bahrain, and other regional sites [1, 4].

Casualties among U.S. forces have been confirmed. At least three U.S. service members died [5]. Additionally, dozens of U.S. personnel were wounded during the strikes [5].

Israeli officials said that missiles struck Tel Aviv [4]. While some reports described the city as burning, other official updates did not mention widespread fires [1, 5].

The retaliatory strikes occur as the regional conflict escalates, with the IRGC utilizing a heavy, multi-layered approach to penetrate defense systems [1, 2].

At least three U.S. service members died

The transition to the 37th wave of Operation True Promise 4 suggests a sustained, industrial-scale attrition strategy by Iran rather than a single retaliatory event. By simultaneously targeting the U.S. Fifth Fleet in Bahrain and personnel in Iraq and Israel, Tehran is signaling that it views U.S. regional support as a primary target, potentially aiming to force a U.S. military withdrawal from the Middle East.