Kris Jenner has confirmed she previously used the weight-loss medication Ozempic before discontinuing the drug due to severe side effects [1, 2, 3].

The admission addresses long-standing public speculation regarding the source of Jenner's weight loss and highlights the physical toll associated with the drug's use [1, 2, 3].

Jenner discussed her experience during an appearance on the SHE MD podcast on May 5, 2024 [3]. During the interview, the 70-year-old matriarch said she wanted to clear the air about rumors and note that she tried the medication before it became a "Hollywood trend" [1, 3].

While the drug is widely used for weight management, Jenner described a negative reaction to the treatment. "I tried Ozempic once and it made me extremely nauseous — I couldn’t even work," Jenner said [3].

Jenner said that she remained on the medication for a short period [2]. She said she stopped the treatment because the side effects were too severe to manage [2].

The podcast, hosted by Dr. Thaïs Aliabadi and Mary Alice Haney, provided a platform for Jenner to discuss her health journey, and the specific impact of the drug's side effects on her professional life [3].

"I tried Ozempic once and it made me extremely nauseous — I couldn’t even work."

Jenner's public admission reflects a growing trend of high-profile figures acknowledging the use of GLP-1 agonists for weight loss. By emphasizing the debilitating side effects that hindered her ability to work, her account provides a counter-narrative to the perceived ease of pharmaceutical weight loss, shifting the conversation toward the medical risks and personal tolerability of these medications.