Mayo Clinic in Jacksonville, Florida, is providing advanced radiation therapy, including carbon-ion and proton treatments, to cancer patients at its campus.
These heavy-particle modalities allow clinicians to target aggressive or treatment-resistant cancers with greater precision. By utilizing personalized treatment plans, the oncology team aims to improve outcomes for patients facing the most difficult stages of their cancer journey.
Central to these operations is the Duan Family Building, which opened in 2024 [1]. The new facility spans 228,000 square feet [1] and represents a $320 million investment in oncology infrastructure [2]. The building was designed to house the specialized equipment and staff required for high-precision radiation delivery.
While the building opened in 2024, the specific carbon-ion program began operation on June 16, 2025 [2]. This capability follows an earlier announcement by Gov. Ron DeSantis that new forms of radiation treatment would be available within two years [3].
Radiation therapists and the broader oncology team at the Jacksonville site manage the delivery of these modalities. The process involves a combination of heavy-particle therapy, and individualized planning to ensure the radiation reaches the tumor while sparing surrounding healthy tissue.
Mayo Clinic said the goal is to provide the most effective and personalized radiation treatments available. The facility focuses on supporting patients through the physical and emotional challenges of the treatment process.
“The new facility spans 228,000 square feet”
The integration of carbon-ion therapy in the U.S. marks a significant shift toward heavy-particle radiation, which is often more effective than traditional X-rays for certain dense tumors. By consolidating these technologies within a dedicated $320 million facility, Mayo Clinic is positioning Jacksonville as a regional hub for advanced oncology, reducing the need for patients with resistant cancers to seek such specialized care abroad.
