Rattlesnake Proteins 10 Times More Potent Than Antivenom in Lab Tests

University of Maryland researchers discovered that combining blood proteins from western diamondback rattlesnakes provides unprecedented neutralizing power against various dangerous snake venoms [1, 2].

This discovery could fundamentally change how doctors treat venomous snakebites by utilizing the natural evolutionary defenses snakes developed to survive their own toxins [1, 2].

The research team focused on identifying a new approach to treatment by isolating specific proteins found in the blood of the western diamondback rattlesnake. In laboratory tests, these combinations of blood proteins were found to be 10 times more potent than current antivenom [1, 2].

Traditional antivenoms often target specific species or require large quantities of antibodies. The Maryland team instead looked at the proteins that snakes evolved to protect themselves from toxicity. A researcher from the University of Maryland said the team achieved "…unprecedented neutralizing power..." through these combinations ^[1].

By mimicking these biological shields, the researchers were able to neutralize the venom of multiple dangerous snake species. Another researcher from the University of Maryland said the process involves "…using the same toxin-blocking proteins that snakes evolved to protect themselves" ^[2].

The lab results suggest that a protein-based approach may be more efficient than existing antibody-based therapies. This method relies on "…combinations of blood proteins..." to block the action of toxins more effectively ^[1].

While the tests were conducted in a laboratory setting, the results indicate a potential shift in the development of next-generation antivenoms. The researchers aim to refine these combinations to ensure they can be safely applied in clinical settings to save lives after a bite.