UNAIDS said Monday that global funding cuts and rising inequality are threatening decades of progress in the fight to eliminate HIV/AIDS [1, 2].

The warning comes as a sharp decline in financial support jeopardizes the delivery of life-saving programs and human-rights-based responses across the globe.

Speaking on the opening day of the 26th International AIDS Conference in Rio de Janeiro, Brazil, officials from the Joint United Nations Programme on HIV/AIDS highlighted a precarious financial landscape [3, 4]. The agency said that international funding for the virus fell by nearly a fifth in 2025 [5].

Specific data on the decline varies by report. One analysis indicates that global funding fell by 18% in 2025 [2]. Other reports said that funding dropped by $2 billion last year, falling from $8.3 billion to $6.2 billion [6].

UNAIDS said these losses were largely due to reduced assistance from the U.S. and broader economic inequality [7]. The agency said these cuts have triggered a wider global exit in support for HIV initiatives [8].

Beyond the financial shortfall, the organization cited setbacks to human rights and growing social inequality as primary barriers to eliminating the epidemic [1, 2]. These factors combine to create an environment where vulnerable populations may lose access to essential care, potentially leading to a resurgence of the disease.

The conference in Rio de Janeiro serves as a critical juncture for member states to address the gap between current funding levels and the resources required to meet global elimination targets [3, 4].

Global HIV/AIDS funding fell by $2 billion in 2025

The significant drop in funding, particularly from a primary donor like the U.S., suggests a shift in geopolitical priorities that may undermine global health security. If the 18% to 24% funding gap is not closed, the infrastructure for testing and treatment may collapse in high-burden regions, reversing years of clinical gains and increasing the risk of new, uncontrolled outbreaks.