At least one in four former NFL players who died between 2016 and 2021 had chronic traumatic encephalopathy (CTE) [1].
The findings highlight the long-term neurological risks associated with repeated head trauma in professional football. This data provides a window into how brain disease manifests in athletes after their careers end.
The research was conducted by Mass General Brigham, Boston University, and the Concussion & CTE Foundation [3]. The team analyzed the brains of former players to estimate the prevalence of the disease across a specific time span [3].
According to the study, at least 25% of the former players who died during the five-year period from 2016 to 2021 were found to have CTE [1], [2]. The research focused on this window to better understand the frequency of the pathology in the league's alumni [2].
CTE is a degenerative brain disease found in people with a history of repetitive head trauma. The study sought to clarify the link between the physical demands of the sport, and long-term brain health risks [3], [4].
Researchers in the Boston area utilized post-mortem examinations to identify the disease [3]. The results suggest that a significant portion of the player population suffers from the condition regardless of the era in which they played [1].
This reporting comes as the medical community continues to investigate how to diagnose and treat brain injuries in living patients [4]. The current study relies on brain tissue examined after death to confirm the presence of the disease [3].
“At least one in four former NFL players who died between 2016 and 2021 had CTE”
This study reinforces the correlation between professional football and permanent brain damage. By establishing a prevalence rate of at least 25% among a specific cohort of deceased players, the research provides a baseline for the NFL and medical professionals to evaluate the effectiveness of current concussion protocols and safety equipment designed to reduce head impact.


