UK Health Secretary Wes Streeting resigned from the cabinet on Thursday, May 14, 2026 [1], and called for a leadership contest to replace Prime Minister Sir Keir Starmer.

The departure of a senior cabinet minister marks a significant escalation in internal party turmoil and threatens the stability of the current government.

Streeting, a Labour MP, said that he had lost confidence in the leadership of Sir Keir Starmer [2]. In a public statement, he cited a "drift" at the top of the government as a primary reason for his decision to step down [3].

Streeting specifically pointed to the results of recent local elections as a catalyst for his resignation. "The local election results were unprecedented — both in terms of the scale of the defeat and the consequences of that failure," Streeting said [4].

The Health Secretary argued that the current leadership is incapable of guiding the party through the next electoral cycle. "It is now clear that you will not lead the Labour Party into the next general election," Streeting said [5].

By calling for a formal leadership contest, Streeting is urging the party to oust Starmer and select a new leader to steer the government. This move places the Prime Minister under intense pressure from within his own ranks as the party grapples with the fallout from the local voting results [2].

Sir Keir Starmer has not yet responded to the specific demand for a leadership contest following the resignation [1].

"I have lost confidence in Sir Keir Starmer’s leadership."

The resignation of a high-profile minister like Wes Streeting suggests that the dissatisfaction within the Labour Party extends beyond the rank-and-file to the inner circle of government. By explicitly linking the resignation to 'unprecedented' local election losses, Streeting is framing the Prime Minister's position as tenable only if the party undergoes a leadership change to avoid further electoral decline.